Evaluation of persistent thrombocytosis

Screening evaluation includes CBC/differential, blood smear, history and physical examination, and ferritin, as described in UpToDate content on evaluation of thrombocytosis. Clinical emergencies and complications (eg, thrombosis, bleeding) should be managed without delay by evaluation of thrombocytosis.

MPN: myeloproliferative neoplasm; CBC: complete blood count.
* Definitions:

Worrisome findings on smear: Leukemic blasts, leukoerythroblastosis
Persistent thrombocytosis: Platelets >450,000/microL confirmed on repeat CBC
Vasomotor symptoms: Erythromelalgia, flushing, pruritus
Constitutional symptoms: Fever, sweats, weight loss
Unusual thrombotic presentations (eg, unusual or multiple sites; <45 years old; unexplained, unprovoked, or recurrent thrombosis)

¶ Refer to UpToDate content on evaluation of thrombocytosis for details.
Δ Refer to UpToDate content on diagnostic testing for MPNs for details.

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Evaluation of persistent thrombocytosis