URI: upper respiratory tract infection; PFAPA: periodic fever, aphthous stomatitis, pharyngitis, and adenopathy.
* Recurrent fever: febrile episodes, separated by periods of normal temperature, occurring over months to years.
¶ Refer to UpToDate topics for evaluation of monogenic periodic fever syndromes and other autoinflammatory disorders.
Δ Refer to appropriate UpToDate topics for evaluation of these disorders. ◊ Refer to UpToDate topics on laboratory evaluation of the immune system and approach to the child with recurrent infections.
Original figure modified for this publication. From: Manthiram K, Long SS, Edwards K. Prolonger, recurrent, and periodic fever syndromes. In: Principles and Practice of Pediatric Infectious Disease, 5th ed, Long S, Probert C, Fischer M (Eds), Elsevier, Philadelphia 2018. Illustration used with the permission of Elsevier Inc. All rights reserved.
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