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The associations of different elevated biomarkers with acute kidney injury, proteinuria, and length of hospital stay in Puumala hantavirus infection[1-7]

The associations of different elevated biomarkers with acute kidney injury, proteinuria, and length of hospital stay in Puumala hantavirus infection[1-7]
Acute kidney injury IL-6, PTX3, IDO, suPAR, GATA-3, Gal-3BP
Proteinuria IL-6, CRP, suPAR
Length of hospitalization IL-6, PTX3, IDO, cf-DNA, suPAR, Gal-3BP
IL-6: interleukin 6; PTX3: pentraxin 3; IDO: indoleamine 2,3-dioxygenase; suPAR: soluble urokinase-type plasminogen activator receptor; GATA-3: GATA binding protein 3; Gal-3BP: Galectin-3-binding protein; CRP: C-reactive protein; cf-DNA: cell-free DNA.
References:
  1. Outinen TK, Mäkelä SM, Ala-Houhala IO, et al. The severity of Puumala hantavirus induced nephropathia epidemica can be better elevated using plasma interleukin-6 than C-reactive protein determinations. BMC Infect Dis 2010; 10:132.
  2. Outinen TK, Mäkelä S, Huhtala H, et al. High pentraxin-3 plasma levels associated with thrombocytopenia in acute Puumala hantavirus-induced nephropathia epidemica. Eur J Clin Microbiol Infect Dis 2012; 31:957.
  3. Outinen TK, Mäkelä SM, Ala-Houhala IO, et al. High activity of indoleamine 2,3-dioxygenase is associated with renal insufficiency in Puumala hantavirus induced nephropathia epidemica. J Med Virol 2011; 83:731.
  4. Outinen TK, Kuparinen T, Jylhävä J, et al. Plasma cell-free DNA levels are elevated in acute Puumala hantavirus infection. PLoS One 2012; 7:e31455.
  5. Outinen TK, Tervo L, Mäkelä S, et al. Plasma levels of soluble urokinase-type plasminogen activator receptor associate with the clinical severity of acute Puumala hantavirus infection. PLoS One 2013; 8:e71335.
  6. Libraty DH, Mäkelä S, Vlk J, et al. The degree of leukocytosis and urine GATA-3 mRNA levels are risk factors for severe acute kidney injury in Puumala virus nephropathia epidemica. PLoS One 2017; 7:e35402.
  7. Hepojoki J, Strandin T, Hetzel U, et al. Acute hantavirus infection induces galectin-3-binding protein. J Gen Virol 2014; 95:2356.
Adapted from: Mustonen J, Outinen T, Laine O, et al. Kidney disease in Puumala hantavirus infection. Infect Dis (Lond) 2017; 49:321.
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