Society guideline links: Thrombotic microangiopathies (TTP, HUS, and related disorders)

Introduction — 

This topic includes links to society and government-sponsored guidelines from selected countries and regions around the world. We will update these links periodically; newer versions of some guidelines may be available on each society's website. Some societies may require users to log in to access their guidelines.

The recommendations in the following guidelines may vary from those that appear in UpToDate topic reviews. Readers who are looking for UpToDate topic reviews should use the UpToDate search box to find the relevant content.

International

●International Society on Thrombosis and Haemostasis (ISTH): Guidelines for management of thrombotic thrombocytopenic purpura, focused update (2025)

•ISTH: Good practice statements (GPS) for the clinical care of patients with thrombotic thrombocytopenic purpura (2020)

•ISTH: Guidelines for the diagnosis of thrombotic thrombocytopenic purpura (2020)

•ISTH: Guidelines for treatment of thrombotic thrombocytopenic purpura (2020)

●Kidney Disease: Improving Global Outcomes (KDIGO): Controversies conference – The role of complement in kidney disease: Conclusions, 2022 (published 2024)

●HUS International: An international consensus approach to the management of atypical hemolytic uremic syndrome in children (2016)

United States

●Centers for Disease Control and Prevention (CDC): Recommendations for diagnosis of Shiga toxin-producing Escherichia coli infections by clinical laboratories (2009)

Europe

●European Paediatric Study Group for HUS: Guideline for the investigation and initial therapy of diarrhea-negative hemolytic uremic syndrome (2009)

United Kingdom

●British Society for Haematology (BSH): Guideline for diagnosis and management of thrombotic thrombocytopenic purpura and thrombotic microangiopathies (2023)

India

●Indian Society of Pediatric Nephrology (ISPN): Hemolytic uremic syndrome in a developing country – Consensus guidelines (2019)

Australia–New Zealand

●Consensus opinion on diagnosis and management of thrombotic microangiopathy in Australia and New Zealand (2018)

Japan

●[In English] Diagnostic and treatment guidelines for thrombotic thrombocytopenic purpura (TTP) in Japan (2023)

●[In English] Japanese Society of Nephrology (JSN) and Japan Pediatric Society (JPS): Clinical guides for atypical hemolytic uremic syndrome in Japan (2016)

●[In Japanese] JSN and JPS: Clinical guides for atypical hemolytic uremic syndrome in Japan (2016)