McDonald criteria for dissemination in space

Dissemination in space is defined as the development of lesions in distinct anatomic locations within the central nervous system, indicating a multifocal process.

• An MRI with one or more hyperintense T2 lesions that are characteristic of multiple sclerosis in at least two of four MS-typical regions of the central nervous system:
  • Periventricular
  • Cortical or juxtacortical
  • Infratentorial
  • Spinal cord
• Development of an additional clinical attack characteristic of multiple sclerosis, supported by objective clinical evidence, that implicates a different central nervous system site