McDonald criteria for dissemination in time

Dissemination in time requires the development or appearance of new central nervous system lesions over time.

• The development of an additional clinical attack, supported by objective clinical evidence, that is characteristic of multiple sclerosis
• An MRI of the brain and/or spinal cord with the simultaneous presence of gadolinium-enhancing and nonenhancing lesions at any time, or by a new hyperintense T2 and/or gadolinium-enhancing lesion(s) on follow-up MRI, irrespective of its timing with reference to a baseline scan
• Finding of cerebrospinal fluid-specific oligoclonal bands (as a substitute for dissemination in time)