Malformation rates for four antiseizure medication monotherapies at different doses at conception

Rate of congenital malformations for the four monotherapies (valproate, phenobarbital, carbamazepine, and lamotrigine) at different doses at conception. Black squares indicate rate for each drug and dose; horizontal lines indicate corresponding 95% confidence intervals.

Data from: Tomson T, Battino D, Bonizzoni E, et al. Comparative risk of major congenital malformations with eight different antiepileptic drugs: a prospective cohort study of the EURAP registry. Lancet Neurol 2018; 17:530.

Modified from: Tomson T, Battino D. Teratogenic effects of antiepileptic drugs. Lancet Neurol 2012; 11:803. doi: 10.1016/S1474-4422(12)70103-5. PMID: 22805351.

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خرید پکیج

Malformation rates for four antiseizure medication monotherapies at different doses at conception