Risk stratification schema for localized prostate cancer, according to the National Comprehensive Cancer Network (NCCN)

• T1c AND
• Grade group 1 AND
• PSA <10 ng/mL AND
• Fewer than 3 prostate biopsy fragments/cores positive, ≤50% cancer in each fragment/core AND
• PSA density <0.15 ng/mL/g

• T1 to T2a AND
• Grade group 1 AND
• PSA <10 ng/mL AND
• Does not qualify for very low risk

• No high or very high risk features
• No more than one intermediate risk factor:
  • T2b to T2c OR
  • Grade group 2 or 3 
  • PSA 10 to 20 ng/mL

AND

• Grade group 1 or 2

AND

• Percentage of positive biopsy cores <50%

• No high or very high risk features
• Two or three of the intermediate risk factors:
  • T2b to T2c
  • Grade group 2 or 3
  • PSA 10 to 20 ng/mL

AND/OR

• Grade group 3

AND/OR

• ≥50% of positive biopsy cores

• No very high risk features

AND

• T3a OR
• Grade group 4 or 5 OR
• PSA >20 ng/mL