Genes associated with multiple, unusual, or severe allergies

Gene abbreviation	Full gene name	Inheritance	Disorder name/phenotype*
CARD11	Caspase recruitment domain family member 11	AD	Immunodeficiency-11B with atopic dermatitis
CARMIL2	Capping protein regulator and myosin 1 linker 2	AR	Immunodeficiency 58
CTLA4	Cytotoxic T-lymphocyte-associated protein 4	AD	Autoimmune lymphoproliferative syndrome (ALPS), type V
DOCK8	Dedicator of cytokinesis 8	AR	Hyper-IgE recurrent infection syndrome 2
FOXP3	Forkhead box P3	XLR	Immunodysregulation, polyendocrinopathy, and enteropathy, X-linked (IPEX) syndrome
PGM3	Phosphoglucomutase 3	AR	Immunodeficiency-vasculitis-myoclonus syndrome
SPINK5	Serine peptidase inhibitor, Kazal type 5	AR	Netherton syndrome/ichthyosiform erythroderma with hypotrichosis and hyper-IgE
WAS	Wiskott-Aldrich syndrome	XLR	Wiskott-Aldrich syndrome (WAS)/eczema, thrombocytopenia, and immunodeficiency
WIPF1	WAS/WASL-interacting protein family member 1	AR	Wiskott-Aldrich syndrome 2

Clinical signs may be present that warrant evaluation for the presence of primary immunodeficiency. Please note that the above table is not comprehensive.

AD: autosomal dominant; AR: autosomal recessive; IgE: immunoglobulin E; XLR: X-linked recessive; OMIM: Online Mendelian Inheritance in Man.
* The phenotypic descriptions were derived from OMIM phenotype labels.

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Genes associated with multiple, unusual, or severe allergies