Pathologic classification of appendiceal goblet cell carcinoid tumors

	Morphologic criteria
Typical GCC (group A)	Well-defined goblet cells arranged in clusters or a cohesive linear pattern
	Minimal cytologic atypia
	Minimal to no desmoplasia
	Minimal architectural distortion of the appendiceal wall
	Degenerative change with extracellular mucin is acceptable
Adenocarcinoma ex GCC, signet ring cell type (group B)	Goblet cells or signet ring cells arranged in irregular large clusters, but a lack of confluent sheets of cells
	Discohesive single-file or single-cell infiltrating pattern
	Significant cytologic atypia
	Desmoplasia and associated destruction of the appendiceal wall
Adenocarcinoma ex GCC, poorly differentiated carcinoma type (group C)	At least focal evidence of goblet cell morphology
	A component (>1 low-power field or 1 mm²) not otherwise distinguishable from a poorly differentiated adenocarcinoma, which may appear as either (a) gland forming, (b) confluent sheets of signet ring cells, or (c) undifferentiated carcinoma

The classification is based on morphologic features at the primary site (appendix) only.

GCC: goblet cell carcinoid.

From: Tang LH, Shia J, Soslow RA, et al. Pathologic classification and clinical behavior of the spectrum of goblet cell carcinoid tumors of the appendix. Am J Surg Pathol 2008; 32:1429. DOI: 10.1097/PAS.0b013e31817f1816. Copyright © 2008. Reproduced with permission from Wolters Kluwer Health. Unauthorized reproduction of this material is prohibited.

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Pathologic classification of appendiceal goblet cell carcinoid tumors