Version May 2024
| IgG | IgA | IgM | IgE | IgD | |
| Serum level (adult) | 700 to 1600 mg/dL | 70 to 400 mg/dL | 50 to 400 mg/dL | 0 to 100 international units/mL | <15.3 mg/dL |
| Polymerization | Monomer | Monomer, dimer | Pentamer, hexamer | Monomer | Monomer |
| Distribution | Tissue | Mucosal surfaces | Intravascular | Bound to mast cell and basophils | B cell membrane bound on unswitched B cells; may bind to mast cells and basophils |
| Subclasses | IgG1, IgG2, IgG3, IgG4 | IgA1, IgA2 | None | None | None |
| Hinge region | Yes | Yes | No | No | Yes |
| Heavy chain domains (CH) | 3 | 3 | 4 | 4 | 3 |
| Serum half-life | 21 days | 6 days | 5 days | 2 days | 3 days |
| Placental transfer | Yes | No | No | No | No |
| Activation of classical complement pathway | Yes (IgG3>IgG1>IgG2>IgG4) | No | Yes, in pentameric form | No | No |
| Activation of alternative complement pathway | No | Yes (IgA1) | No | No | No |
| Basophil/mast cell binding | No | No | No | Yes | Probably |
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