Uterine cancer: Frequency of nodal metastases by risk factors*

Risk factor		Pelvic			Aortic
Risk factor		N+	%	p-value	N+	%	p-value
Histology				<0.001			<0.001
Endometrioid, grade 1	(n = 1516)	60	4.0		30	2.0
Endometrioid, grade 2	(n = 1129)	82	7.3		41	3.6
Endometrioid, grade 2	(n = 580)	103	17.8		52	9.0
Serous (SER)	(n = 805)	201	25.0		141	17.5
Clear cell (CLC)	(n = 274)	55	20.1		34	12.4
Carcinosarcoma (CLC)	(n = 322)	68	21.1		49	15.2
Mixed, NOS(OMX)	(n = 318)	64	20.1		42	13.2
Other (OTH)	(n = 188)	29	15.4		24	12.8
Myometrial invasion				<0.001			<0.001
Endometrium only (EN)	(n = 1184)	31	2.6		14	1.2
Inner half (IN)	(n = 2477)	172	6.9		93	3.8
Outer half (OU)	(n = 1304)	361	27.7		229	17.6
Serosa (SE)	(n = 156)	95	60.9		74	47.4
Peritoneal cytology				<0.001			<0.001
Negative	(n = 4364)	459	10.5		266	6.1
Positive	(n = 532)	169	31.8		121	22.7
Adnexal involvement				<0.001			<0.001
Negative	(n = 4629)	464	10.0		261	5.6
Positive	(n = 475)	195	41.0		149	31.4
Other extra-uterine metastasis				<0.001			<0.001
Negative	(n = 4567)	404	8.9		237	5.2
Positive	(n = 565)	258	45.7		176	31.2
Lympho-vascular space involvement				<0.001			<0.001
Negative	(n = 3722)	151	4.1		85	2.3
Positive	(n = 1323)	496	37.5		315	23.8
Menopausal status				<0.001			<0.001
Pre-menopause	(n = 389)	30	7.7		18	4.6
Post-menopause	(n = 3366)	441	13.1		289	8.6

N+: number of patients with nodal metastases; NOS: not otherwise specified.
* Patients with both pelvic and aortic node status and variable information.

Reproduced from: Creasman WT, Ali S, Mutch DG, et al. Surgical-pathological findings in type 1 and 2 endometrial cancer: An NRG Oncology/Gynecologic Oncology Group study on GOG-210 protocol. Gynecol Oncol 2017; 145:519. Table used with the permission of Elsevier Inc. All rights reserved.

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Uterine cancer: Frequency of nodal metastases by risk factors*