Condition | Observed impact of central sensitization |
Osteoarthritis | - QST and neuroimaging abnormalities improved after joint replacement
- Correlated with pain severity, poor outcome
- Correlated with opioid use
|
RA | - Higher pain and disease activity scores but no correlation with inflammation/damage
- Correlated with neuropathic symptoms, QST ratings
- Correlated with adverse outcome, lack of remission, inappropriate therapy
|
Spondyloarthritis | - Worse disease activity scores and outcomes
- Poorer response/inappropriate use of biologics
|
SLE | - Greater mood and sleep disturbances
- Poorer outcome
|
Chronic LBP | - Greater pain, mood disturbances, adverse outcome
|
Joint hypermobility syndrome | - Correlated with pain severity, poor outcome
|
Chronic whiplash | - Correlated with pain severity, poor outcome, cognitive disturbances
|
Carpal tunnel syndrome | - Correlated with poor surgical outcome
|
Lateral epicondylitis | - Correlated with pain severity, duration, poor response to treatment
|