Version May 2024
Sclerosing agent:
Note: Recommended for use in small vessels (vessel diameter <1 mm) (Ref).
IV: 0.1 to 1 mL (depends on length and size of vein) per injection site; not to exceed a cumulative dose of 10 mL per visit.
There are no dosage adjustments provided in the manufacturer’s labeling.
There are no dosage adjustments provided in the manufacturer’s labeling.
Refer to adult dosing.
There are no adverse reactions listed in the manufacturer's labeling.
Recent superficial or deep thrombophlebitis (6 months to 2 years); varicose veins caused by abdominal or pelvic tumors; potential underlying arterial disease; renal or cardiac insufficiencies accompanied by venous stasis or dilatation; angina pectoris; local or systemic infections; hyperthyroidism; uncontrolled diabetes mellitus
Concerns related to adverse effects:
• Hypersensitivity: Mild or severe allergic reactions may occur.
Disease-related concerns:
• Thromboembolism: Use with caution in patients with history of deep vein thrombosis or at increased risk for thromboembolism (eg, oral contraceptive use). Pulmonary embolism may occur if the thrombus enters the systemic circulation.
Other warnings/precautions:
• Appropriate use: Administration should be performed by health care provider trained in sclerosing technique. Avoid extravasation and arterial injection due to risk of ischemia and necrosis of surrounding tissues.
Not available in the US
No
Excipient information presented when available (limited, particularly for generics); consult specific product labeling.
Solution, Injection:
Sclerodex: Dextrose 250 mg and sodium chloride 100 mg per mL (10 mL)
For IV administration only. Avoid extravasation and arterial injection due to risk of ischemia and necrosis of the surrounding tissues. Separate injection sites by ~2 inches (5 cm).
Sclerosing agent: Local treatment of varicose veins, especially small vessels and communicating veins of the superficial venous system; as adjunct to the surgical treatment of varicose veins of the lower limbs
None known.
There are no known significant interactions.
Hypersensitivity reactions; signs/symptoms of deep vein thrombosis/pulmonary embolism.
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