Recommendations for discontinuation of direct oral anticoagulants in the perioperative time period

Low risk for bleeding				High risk for bleeding
DTI		Factor Xa inhibitor		DTI		Factor Xa inhibitor
CrCl	Discontinue	CrCl	Discontinue	CrCl	Discontinue	CrCl	Discontinue
<15	No data, ≥96 hours	<15	No data, ≥48 hours	<15	No data	<30	No data, ≥72 hours
15 to 29	≥72 hours	15 to 29	≥36 hours	15 to 29	≥120 hours	≥30	≥48 hours
30 to 49	≥48 hours	≥30	≥24 hours	30 to 49	≥96 hours
50 to 79	≥36 hours			50 to 79	≥72 hours
≥80	≥24 hours			≥80	≥48 hours

DTI: direct thrombin inhibitor; CrCl: creatinine clearance.

Adapted from: Doherty JU, Gluckman TJ, Hucker WJ, et al. 2017 ACC expert consensus decision pathway for periprocedural management of anticoagulation in patients with nonvalvular atrial fibrillation: A report of the American College of Cardiology Clinical Expert Consensus Document Task Force. J Am Coll Cardiol 2017; 69:871.

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خرید پکیج

Recommendations for discontinuation of direct oral anticoagulants in the perioperative time period