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Harmonized recommendations for ototoxicity surveillance in survivors of childhood, adolescent, and young adult cancer

Harmonized recommendations for ototoxicity surveillance in survivors of childhood, adolescent, and young adult cancer
Hearing loss
General recommendation
Survivors treated with cisplatin, with or without high-dose carboplatin (>1500 mg/m2), or head or brain radiotherapy ≥30 Gy and their health care providers should be aware of the risk of hearing loss
Who needs surveillance and how often should surveillance be performed?
Surveillance for hearing loss is recommended for survivors treated with cisplatin, with or without high-dose carboplatin (>1500 mg/m2), or head or brain radiotherapy ≥30 Gy to begin no later than the end of treatment and to be done annually for children younger than 6 years of age, every other year for children 6 to 12 years of age, and every 5 years for adolescents and young adults older than 12 years of age
Hearing loss surveillance might be reasonable for survivors who had placement of CSF shunts to begin no later than the end of treatment and be repeated every 5 years thereafter
What surveillance modality should be used?
Pure tone conventional audiometry testing is recommended for survivors ≥6 years of age at 1000 to 8000 Hz, and additional testing with high-frequency audiometry at >8000 Hz is recommended whenever equipment is available; referral to an audiologist for more extensive testing is recommended for survivors <6 years of age
What should be done when atypical measurements are identified?
Referral to an audiologist or auditory clinic is recommended for any survivor who has symptoms suggesting hearing loss or atypical audiological test results showing a loss of more than 15 dB absolute threshold level (1000 to 8000 Hz)
Tinnitus
General recommendation
Survivors treated with cisplatin, with or without high-dose carboplatin (>1500 mg/m2), or head or brain radiotherapy ≥30 Gy and their health care providers should be aware of the risk of tinnitus. Referral to an audiologist is recommended for survivors who have symptoms of tinnitus
CSF: cerebral spinal fluid.
Original figure modified for this publication. From: Clemens E, van den Heuvel-Eibrink MM, Mulder RL, et al. Recommendations for ototoxicity surveillance for childhood, adolescent, and young adult cancer survivors: a report from the International Late Effects of Childhood Cancer Guideline Harmonization Group in collaboration with the PanCare Consortium. Lancet Oncol 2019; 2D:e29. Table used with the permission of Elsevier Inc. All rights reserved.
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