Risk stratification in primary myelofibrosis

This algorithm presents our approach to risk stratification for PMF and should be used in conjunction with related UpToDate topics.
Use of alternative prognostic tools is acceptable in settings where molecular and/or cytogenetic tests are limited, as described in related UpToDate topics.

GIPSS: genetically inspired prognostic scoring system; Hb: hemoglobin; HMR: high molecular risk; MIPSS70+ v2.0: mutation-enhanced international prognostic scoring system, version 2.0; PMF: primary myelofibrosis.

* Cytogenetic categories:

Very high risk: single or multiple abnormalities of –7, i(17q), inv(3)/3q21, 12p–/12p11.2, 11q–/11q23, or other autosomal trisomies not including +8/+9 (eg, +21, +19).
Favorable: normal karyotype or sole abnormalities of +9, 13q–, 20q–, chromosome 1 translocation/duplication, or sex chromosome abnormality including –Y.
Unfavorable: all other abnormalities.

Graphic 120377 Version 3.0

خرید پکیج

Risk stratification in primary myelofibrosis