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Risk stratification in primary myelofibrosis

Risk stratification in primary myelofibrosis
  • This algorithm presents our approach to risk stratification for PMF and should be used in conjunction with related UpToDate topics.
  • Use of alternative prognostic tools is acceptable in settings where molecular and/or cytogenetic tests are limited, as described in related UpToDate topics.

GIPSS: genetically inspired prognostic scoring system; Hb: hemoglobin; HMR: high molecular risk; MIPSS70+ v2.0: mutation-enhanced international prognostic scoring system, version 2.0; PMF: primary myelofibrosis.

* Cytogenetic categories:
  • Very high risk: single or multiple abnormalities of –7, i(17q), inv(3)/3q21, 12p–/12p11.2, 11q–/11q23, or other autosomal trisomies not including +8/+9 (eg, +21, +19).
  • Favorable: normal karyotype or sole abnormalities of +9, 13q–, 20q–, chromosome 1 translocation/duplication, or sex chromosome abnormality including –Y.
  • Unfavorable: all other abnormalities.
Graphic 120377 Version 3.0