- Males more often than females
- Intestinal-type histology
- Frequently located at fundus and body
- JAK2 amplification
- PIK3CA mutation (80% subtype) inactivating in the kinase domain (exon 20)
- ARID1A (55%) mutations
- Immune cell signaling enrichment
| - Females predominate
- Intestinal-type histology
- An older age at diagnosis
- Mutation in one of several different DNA mismatch repair genes (ie, MLH1 or MSH2)
- Lacks targetable amplifications
| - Males more often than females
- Intestinal-type histology
- Frequently located at EGJ
- RTK-RAS amplifications (EGFR, ERRB2, ERRB3, VEGFA, FGFR2, MET, NRAS/KRAS, JAK2, and PIK3CA)
- Amplification of cell cycle genes
- TP53 mutations
| - Males = females
- Distal location
- Diffuse-type histology
- An early age at diagnosis
- Recurrent CDH1 inactivation, RHOA mutation, ARID1A mutation
|
- Frequently EBV-positive
- Intermediate prognosis
- Mutations in ARID1A, APC, KRAS, PIK3CQA, and SMAD4
| - Distal stomach
- Intestinal-type histology
- Early stage diagnosis
- Favorable prognosis
- Hypermutation
| - TP53 mutation
- Amplification of RTKs
- Intermediate prognosis
| - Diagnosed at younger age
- Diffuse-type histology
- Worse prognosis
- Low number of mutations
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