ﺑﺎﺯﮔﺸﺖ ﺑﻪ ﺻﻔﺤﻪ ﻗﺒﻠﯽ
خرید پکیج
تعداد آیتم قابل مشاهده باقیمانده : 3 مورد
نسخه الکترونیک
medimedia.ir

Classification of diffuse palmoplantar keratoderma

Classification of diffuse palmoplantar keratoderma
Type of diffuse PPK Mode of inheritance Causative genes Pathologic findings Manifestation of PPK Transgrediens Hyperhidrosis Whitish change upon water exposure Development on other areas Spontaneous amputation
Vörner (Unna-Thost) AD KRT1, KRT9 Epidermolytic hyperkeratosis Thick hyperkeratosis – – – – –
Diffuse PPK with DSG1 mutations AD DSG1 Enlarged intercellular spaces and partial separation of keratinocytes Thick hyperkeratosis – Not described Not described Mild onycholysis with yellowish discoloration –
Nagashima AR SERPINB7 Nonepidermolytic hyperkeratosis Mild hyperkeratosis with redness + + + Knees, elbows, and Achilles tendon area –
Diffuse PPK with SERPINA12 mutations AR SERPINA12 Nonepidermolytic hyperkeratosis Mild hyperkeratosis with redness + Not described Symptoms are worsened by water exposure Achilles tendon area and groin area –
Bothnia AD AQP5 Nonepidermolytic hyperkeratosis Mild to thick hyperkeratosis + + + – –
Greither AD KRT1 Nonepidermolytic hyperkeratosis Thick hyperkeratosis + + – Elbows, knees, flexural areas, and Achilles tendon +
Sybert AD Unknown Nonepidermolytic hyperkeratosis Thick hyperkeratosis + Not described – Natal cleft, groin, elbows, knees, posterior aspects of forearms, and anterior aspects of legs +
Mal de Meleda AR SLURP1 Nonepidermolytic hyperkeratosis Severe hyperkeratosis + + – Knees and elbows, perioral erythema, and periorbital erythema Occasionally
Gamborg-Nielsen AR SLURP1 Nonepidermolytic hyperkeratosis Thick hyperkeratosis +
(1 of 4) 		Not described +
(1 of 15) 		Only knuckle pads on the dorsa of the fingers Not described
Acral keratoderma AR Unknown Nonepidermolytic hyperkeratosis Thick, diffuse, and striate hyperkeratosis + Not described – Linear hyperkeratotic lesions over knees, elbows, ankles, and Achilles tendon area +
PPK: palmoplantar keratoderma; AD: autosomal dominant; AR: autosomal recessive.
From: Sakiyama T, Kubo A. Hereditary palmoplantar keratoderma "clinical and genetic differential diagnosis". J Dermatol 2016; 43(3):264-74. https://onlinelibrary.wiley.com/doi/full/10.1111/1346-8138.13219. Copyright © 2016 Japanese Dermatological Association. Reproduced with permission of John Wiley & Sons Inc. This image has been provided by or is owned by Wiley. Further permission is needed before it can be downloaded to PowerPoint, printed, shared or emailed. Please contact Wiley's permissions department either via email: [email protected] or use the RightsLink service by clicking on the 'Request Permission' link accompanying this article on Wiley Online Library (https://onlinelibrary.wiley.com/).
Graphic 120443 Version 2.0

آیا می خواهید مدیلیب را به صفحه اصلی خود اضافه کنید؟