Distinguishing what is considered a prebiotic with the proposed definition

The figure shows candidate as well as accepted prebiotics in that levels of evidence vary, with FOS and GOS being the most researched prebiotics. Prebiotics must be selectively utilized by host microorganisms and have adequate evidence of health benefit for the target host. Dietary prebiotics must not be degraded by the target host enzymes.

CLA: conjugated linoleic acid; PUFA: polyunsaturated fatty acid; FOS: fructooligosaccharides; GOS: galactooligosaccharides; MOS: mannanoligosaccharide; XOS: xylooligosaccharide.

Adapted from: Gibson GR, Hutkins R, Sanders ME, et al. The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of prebiotics. Nat Rev Gastroenterol Hepatol 2017; 14:491. Available at: https://www.nature.com/articles/nrgastro.2017.75. Copyright © 2017 Gibson GR, Hutkins R, Sanders ME, et al. Reproduced under the terms of the Creative Commons Attribution License 4.0.

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Distinguishing what is considered a prebiotic with the proposed definition