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Classification of tumors of the urothelial tract, adapted from the WHO[1]

Classification of tumors of the urothelial tract, adapted from the WHO[1]
Urothelial tumors
Noninvasive urothelial neoplasia
Urothelial papilloma
Inverted urothelial papilloma
Papillary urothelial neoplasm of low malignant potential
Noninvasive papillary urothelial carcinoma, low grade
Noninvasive papillary urothelial carcinoma, high grade
Urothelial carcinoma in situ
Invasive urothelial carcinoma
Histologic subtypes
Nested
Large nested
Tubular and Microcystic
Micropapillary
Lymphoepithelioma-like
Plasmacytoid
Sarcomatoid
Giant cell
Poorly differentiated
Lipid-rich
Clear cell (glycogen-rich)
Divergent differentiation
Urothelial carcinoma with squamous differentiation
Urothelial carcinoma with glandular differentiation
Urothelial carcinoma with trophoblastic differentiation
Squamous cell neoplasms
Urothelial squamous cell papilloma
Verrucous carcinoma of the bladder
Pure urothelial squamous cell carcinoma
Glandular neoplasms
Adenomas
Villous adenoma
Adenocarcinoma
Adenocarcinoma, NOS
Urachal and diverticular neoplasms
Urachal carcinoma
Diverticular carcinoma
Urethral neoplasms
Urethral accessory gland carcinomas
Littre gland carcinoma of the urethra
Skene gland carcinoma of the urethra
Cowper gland carcinoma of the urethra
Tumors of Mullerian type
Clear cell carcinoma
Endometrioid carcinoma
WHO: World Health Organization; NOS: not otherwise specified.
Reference:
  1. Srigley JR, Tsuzuki T, Rubin MA. WHO Classification of Tumours: Urinary and Male Genital Tumours, IARC Press, Lyon 2022.
Graphic 121066 Version 3.0

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