Jansson criteria[1] | Bristol criteria[2] |
Major criteria | Required |
- Radiologically proven osteolytic/sclerotic bone lesion
- Multifocal bone lesions
- PPP or psoriasis
- Sterile bone biopsy with signs of inflammation and/or fibrosis, sclerosis
| - The presence of typical clinical findings (bone pain +/– localized swelling without significant local or systemic features of inflammation or infection)
- The presence of typical radiologic findings (preferably STIR MRI showing bone marrow edema +/– bone expansion, lytic areas and periosteal reaction or plain radiograph showing combination of lytic areas, sclerosis, and new bone formation)
|
Minor criteria | Plus one of the following |
- Normal blood count and good general state of health
- CRP and ESR mildly to moderately elevated*
- Observation time longer than 6 months
- Hyperostosis
- Associated with other autoimmune diseases apart from PPP or psoriasis
- Grade I or II relatives with autoimmune or autoinflammatory disease or with nonbacterial osteomyelitis
| - More than 1 bone (or clavicle alone) involved without significantly raised CRP (CRP <30 g/L)
- Unifocal disease other than clavicle, or CRP >30 g/L, with bone biopsy showing inflammatory changes (plasma cells, osteoclasts, fibrosis, or sclerosis) with no bacterial growth whilst not on antibiotic therapy
|
Threshold of diagnosis: ≥2 major criteria or 1 major plus 3 minor criteria | Threshold of diagnosis: Both 1 AND 2, plus A OR B |