Salivary gland involvement in IgG4-related disease and Sjögren's disease

	IgG4-RD	Sjögren's disease
Gender distribution	2.5:1 male:female ratio	9:1 female:male ratio
Clinical presentation	Mild or no salivary gland dysfunction	Significant salivary gland dysfunction (xerostomia)
Clinical presentation	Persistent salivary gland swelling	Intermittent salivary gland swelling
Circulating antibodies	Serum IgG4 and IgE levels typically elevated	Serum IgG4 and IgE levels usually normal
	Anti-Ro/SSA and anti-LA/SSB rarely present	Anti-Ro/SSA (with or without anti-LA/SSB) commonly present
	ANA detectable in 25% of patients	ANA detectable in 90% of patients
	Rheumatoid factor detected in 25% of patients	Rheumatoid factor detected in 60% of patients
Imaging	No abnormality of salivary glands seen on sialography	Punctate and globular sialectasis seen on sialography

IgG4-RD: immunoglobulin G4-related disease; IgE: immunoglobulin E; ANA: antinuclear antibodies.

Adapted from: Fragoulis GE, Zampeli E, Moutsopoulos HM. IgG4-related sialadenitis and Sjögren's syndrome. SO Oral Dis 2017; 23:152.

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