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Calculator: Genetically inspired international prognostic scoring system (GIPSS) for primary myelofibrosis in adults


Calculator: Genetically inspired international prognostic scoring system (GIPSS) for primary myelofibrosis in adults

 
Karyotype classification:*

Very high risk (VHR) (2 points)

Unfavorable (1 point)

Favorable (0 points)
Driver mutations:

Absence of type 1-like CALR (1 point)
High molecular risk (HMR) mutations:**

ASXL1 mutation (1 point)

SRSF2 mutation (1 point)

U2AF1 Q157 mutation (1 point)

 
Important: Inputs must be complete to perform calculation.

 
Total criteria point count:
 

 

Interpretation

 
GIPSS score (points) Risk group 5-year overall survival Median overall survival (years)
0 Low risk 94% 26.4
1 Intermediate risk - 1 73% 10.3
2 Intermediate risk - 2 40% 4.6
3 to 6 High risk 14% 2.6

 
Notes
  • *Classification of karyotypes:
    • VHR: Single or multiple abnormalities of -7, i(17q), inv(3)/3q21, 12p-/12p11.2, 11q-/11q23, or other autosomal trisomies not including +8/+9 (eg, +21, +19).
    • Favorable: Normal karyotype or sole abnormalities of +9, 13q-, 20q-, chromosome 1 translocation/duplication, or sex chromosome abnormality including -Y.
    • Unfavorable: All other abnormalities.
  • **Classification of HMR mutations:
    • ASXL1 mutation = 1 point
    • SRSF2 mutation = 1 point
    • U2AF1 Q157 mutation = 1 point

 
Only digits 0 to 9 and a single decimal point (".") are acceptable as numeric inputs. Attempted input of other characters into a numeric field may lead to an incorrect result.

Information on this page may not appear correctly if printed.

Legal Notices and Disclaimer

All information contained in and produced by the EBMcalc system is provided for educational purposes only. This information should not be used for the diagnosis or treatment of any health problem or disease. THIS INFORMATION IS NOT INTENDED TO REPLACE CLINICAL JUDGMENT OR GUIDE INDIVIDUAL PATIENT CARE IN ANY MANNER. Click here for full notice and disclaimer.

EBMcalc is Copyright © 1998-2024 Foundation Internet Services, LLC

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