Expanded versus nonexpanded mesenchymal stem or stromal cells

MSCs	Culture-expanded MSCs	Nonexpanded cells
Manufacturing cost	High (usually >$10,000 USD)	Moderate (subject to commercial factors)
Preparation time	Weeks	Hours
Regulation	Extensive	Minimal (varies by location)
Quantity produced and concentration	Quantifiable and essentially unlimited Example: 50 × 10⁶ MSCs per mL after preparation	Unquantifiable and limited by volumes of lipo- or bone marrow aspirate Example: up to 2 × 10⁶ MSCs per mL after preparation
Percentage of MSCs in treatment	High Typically 85 to 100% of nucleated cells Homogenous cell population	Low Typically 0 to 10% of nucleated cells Heterogeneous cell population

MSCs: mesenchymal stem or stromal cells.

Graphic 121597 Version 2.0