Baylor Texas Children's guideline for platelet transfusion for neonatal thrombocytopenia (platelet count <100,000)*

* This algorithm is based on the clinical practice guideline developed by the Baylor College of Medicine Department of Neonatology for neonates with thrombocytopenia with a platelet count <100,000/microL except for infants with neonatal immune-medicated thrombocytopenia. It is intended to be used with the UpToDate content on clinical manifestations, evaluation, and management of neonatal thrombocytopenia. There is a separate clinical algorithm for neonates with neonatal immune-medicated thrombocytopenia.
¶ Major bleeding is defined as a recent episode (within 72 hours) of intracranial bleeding, pulmonary hemorrhage, frank rectal bleeding, and life-threatening bleeding requiring emergent fluid resuscitation or red blood cell transfusion.
Δ In other centers, the clinical status of the patient does not influence the platelet threshold trigger.