|Type of reaction (and other terminology used)
PhysiologicAlso called: toxic, chemotoxic.
HypersensitivityAlso called: allergy-like, allergic-like.
|Timing relative to administration
Within minutes to one hour by definition.Often within seconds.
|Within minutes to one hour by definition.
|Signs and symptoms
|Possibly related to direct chemotoxicity, osmotoxicity, or binding of agent to endogenous molecules.
Mechanism of mild reactions is unclear; direct mast cell activation has been proposed.Some reactions in re-exposed patients may be IgE mediated.
|Most are mild and self-limited.
|Most are mild and self-limited but severe reactions can be fatal.
|High dose and osmolarity, angiography.
|Previous immediate hypersensitivity reaction.
|Allergy testing indicated?
|Yes, especially for moderate to severe reactions. Premedication is usually effective for preventing recurrences of mild reactions.
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