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Proposed terms to characterize medication-related osteonecrosis of the jaw (MRONJ) after treatment

Proposed terms to characterize medication-related osteonecrosis of the jaw (MRONJ) after treatment
Term Mucosal coverage Symptom/pain Sign of infection/inflammation Radiographic
Resolved Complete healing No pain None Trabecular pattern, formation lamina dura resorbed
Improving Significant improvement (>50% of mucosal coverage) Significant improvement (>50% reduction of pain, VAS) Significant improvement (no signs of infection/inflammation) Improved trabecular pattern, signs of sequestra
Stable Mild improvement (<50% of mucosal coverage) Mild improvement (<50% reduction of pain, VAS) Mild improvement (mild signs of infection/inflammation) No changes
Progressive No improvement or worsening No improvement or worsening No improvement Lytic changes, decreasing trabeculation, increased size of radiographic lesion
VAS: visual analog scale.
From: Yarom N, Shapiro CL, Peterson DE, et al. Medication-Related Osteonecrosis of the Jaw: MASCC/ISOO/ASCO Clinical Practice Guideline. J Clin Oncol 2019. Reprinted with permission. Copyright © 2019 American Society of Clinical Oncology. All rights reserved.
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