NCI CTCAE v5.0 osteonecrosis of the jaw

Adverse event	Grade 1	Grade 2	Grade 3	Grade 4	Grade 5
Osteonecrosis of jaw	Asymptomatic; clinical or diagnostic observations only; intervention not indicated	Symptomatic; medical intervention indicated (eg, topical agents); limiting instrumental ADL	Severe symptoms; limiting self-care ADL; elective operative intervention indicated	Life-threatening consequences; urgent intervention indicated	Death

Osteonecrosis of the jaw is characterized by a necrotic process occurring in the bone of the mandible.

NCI CTCAE: National Cancer Institute Common Terminology Criteria for Adverse Events; ADL: activities of daily living.

Reproduced from: Common Terminology Criteria for Adverse Events (CTCAE), Version 5.0, November 2017, National Institutes of Health, National Cancer Institute. Available at: https://ctep.cancer.gov/protocoldevelopment/electronic_applications/docs/CTCAE_v5_Quick_Reference_8.5x11.pdf (Accessed July 30, 2019).

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