Version June 2024
| Regimen | Dosing | |
| Nonpregnant adults | Doxycycline | 100 mg orally twice daily for at least 12 weeks |
| plus | ||
| Rifampin | 600 to 900 mg orally once daily for at least 12 weeks | |
| plus | ||
| Streptomycin | 1 g intramuscularly or intravenously once daily for the first 14 to 21 days | |
| or | ||
| Doxycycline | 100 mg orally twice daily for at least 12 weeks | |
| plus | ||
| Rifampin | 600 to 900 mg orally once daily for at least 12 weeks | |
| plus | ||
| Gentamicin | 5 mg/kg/day intramuscularly or intravenously in 1 dose for the first 7 to 14 days | |
| Children ≥8 years | Doxycycline | 4.4 mg/kg per day (maximum 200 mg/day) orally in 2 divided doses for at least 12 weeks |
| plus | ||
| Rifampin | 15 to 20 mg/kg per day (maximum 900 mg/day) orally once daily for at least 12 weeks | |
| plus | ||
| Streptomycin | 15 to 40 mg/kg per day (maximum 1 g/day) intramuscularly or intravenously in 1 to 2 doses for the first 14 to 21 days | |
| or | ||
| Doxycycline | 4.4 mg/kg per day (maximum 200 mg/day) orally in 2 divided doses for at least 12 weeks | |
| plus | ||
| Rifampin | 15 to 20 mg/kg per day [maximum 900 mg/day] orally once daily for at least 12 weeks | |
| plus | ||
| Gentamicin | 5 mg/kg/day intramuscularly or intravenously in 1 dose for the first 7 to 14 days | |
| Children <8 years | TMP-SMX | TMP 10 mg/kg per day (maximum 320 mg/day) and SMX 50 mg/kg per day (maximum 1.6 g/day) divided in 2 doses for at least 12 weeks |
| plus | ||
| Rifampin | 15 to 20 mg/kg per day (maximum 900 mg/day) orally once daily for at least 12 weeks | |
| plus | ||
| Streptomycin | 15 to 40 mg/kg per day (maximum 1 g/day) intramuscularly or intravenously in 1 to 2 doses for the first 14 to 21 days | |
| or | ||
| TMP-SMX | TMP 10 mg/kg per day (maximum 320 mg/day) and SMX 50 mg/kg per day (maximum 1.6 g/day) divided in 2 doses for at least 12 weeks | |
| plus | ||
| Rifampin | 15 to 20 mg/kg per day (maximum 900 mg/day) orally once daily for at least 12 weeks | |
| plus | ||
| Gentamicin | 5 mg/kg/day intramuscularly or intravenously in 1 dose for the first 7 to 14 days | |
| Pregnant women* | Ceftriaxone | 2 g intravenously once daily for 4 to 6 weeks |
| plus | ||
| Rifampin | 600 to 900 mg orally once daily for at least 12 weeks | |
| plus | ||
| TMP-SMX | 1 double-strength tablet (160 mg TMP/800 mg SMX) orally twice daily for at least 12 weeks | |
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