The entry criterion is necessary to classify SLE. | |
Entry criterion:
| |
At least 1 clinical criterion required to classify SLE. Additional additive (clinical or immunology) criteria are counted toward the total score. | |
Additive criteria:
| |
Clinical domains and criteria | Weight |
Constitutional | |
Fever | 2 |
Hematologic | |
Leukopenia | 3 |
Thrombocytopenia | 4 |
Autoimmune hemolysis | 4 |
Neuropsychiatric | |
Delirium | 2 |
Psychosis | 3 |
Seizure | 5 |
Mucocutaneous | |
Nonscarring alopecia | 2 |
Oral ulcers | 2 |
Subacute cutaneous or discoid lupus | 4 |
Acute cutaneous lupus | 6 |
Serosal | |
Pleural or pericardial effusion | 5 |
Acute pericarditis | 6 |
Musculoskeletal | |
Joint involvement | 6 |
Renal | |
Proteinuria >0.5 g per 24 hours | 4 |
Renal biopsy Class II or V lupus nephritis | 8 |
Renal biopsy Class III or IV lupus nephritis | 10 |
Immunology domains and criteria | Weight |
Antiphospholipid antibodies | |
Anti-cardiolipin antibodies or anti-beta-2GP1 antibodies or lupus anticoagulant | 2 |
Complement proteins | |
Low C3 or low C4 | 3 |
Low C3 and low C4 | 4 |
SLE-specific antibodies | |
Anti-dsDNA antibodyΔ or anti-Smith antibody | 6 |
A total score of ≥10 and ≥1 clinical criterion are required to classify SLE. | |
Total score |
SLE: systemic lupus erythematosus; ANA: antinuclear antibody; HEp-2: human epithelial type 2; anti-beta-2GP1: anti-beta-2 glycoprotein 1; anti-dsDNA: anti-double-stranded DNA.
* If ANA is absent, do not classify as SLE.
¶ Additional criteria within the same domain will not be counted.
Δ In an assay with 90% specificity against relevant disease controls.آیا می خواهید مدیلیب را به صفحه اصلی خود اضافه کنید؟