Version May 2024
| Term | Definition |
| Hematopoietic cell transplantation (HCT) | Restoration of blood cell production by infusion of hematopoietic cells following treatment with a conditioning regimen (refer to below). Depending on the source of the graft, HCT may also be described as bone marrow transplantation, peripheral blood transplantation, or umbilical cord transplantation. |
| Donor | The person who is the source of the hematopoietic graft. |
| Recipient | The person to whom the graft is administered. |
| Chimerism | Describes the mix of host and donor hematopoiesis in bone marrow and blood. As examples, 100% chimerism refers to purely donor hematopoiesis while 50% chimerism refers to equal contributions from the donor and host. |
| Conditioning regimen | Chemotherapy (and occasionally radiation therapy) used to treat the recipient before infusion of the HCT graft. The intensity of conditioning may be: |
| Myeloablative | Intensive conditioning that fully ablates the recipient's hematopoietic cells. |
| Reduced intensity conditioning or nonmyeloablative conditioning | Less intensive conditioning techniques that enable engraftment but do not fully eradicate host hematopoiesis, resulting in chimerism (refer to above). |
| Graft | Hematopoietic cells (including stem cells and progenitor cells from peripheral blood, bone marrow, or umbilical cord) infused to restore blood cell production; an HCT graft can be: |
| Allogeneic | An HCT graft from another person. |
| Autologous | The donor and recipient are the same person; the graft is collected prior to treatment with a conditioning regimen and later infused to restore blood cell production. |
| Human leukocyte antigen (HLA)-matched | Immunologically matched specimen, based on HLA similarity between donor and recipient; HLA-matched specimens can be: |
| Matched related donor | HLA-matched specimen from a related donor, who is typically a sibling. |
| Matched unrelated donor (MUD) | HLA-matched specimen from an unrelated donor, who is typically identified through a specimen bank. |
| HLA-mismatched | Variable degrees of HLA mismatch; compared to matched grafts, mismatched grafts are more likely to cause graft-versus-host disease (refer to below). |
| Haploidentical | One of two sets of HLA alleles are matched, while the other is mismatched; haploidentical grafts are typically from a parent or a child. |
| Graft-versus-host disease (GVHD) | An immunologic reaction in which an allogeneic graft recognizes host antigens as "foreign" and causes injury to skin, gastrointestinal tract, lung, liver, or other organ systems; GVHD can be acute or chronic, which differ based on time of onset and clinical manifestations. |
| Graft-versus-tumor (GVT) effect | An immunologic reaction of the graft against the malignancy; even in well-matched specimens, subtle degrees of mismatch can induce the beneficial effect of GVT. |
آیا می خواهید مدیلیب را به صفحه اصلی خود اضافه کنید؟
