Changes in the relationship between V_E and VCO₂ during exercise in patients with pulmonary vascular disease

(A) On the left is the relationship of V_E versus VCO₂, and on the right the plot of V_E/VCO₂ versus time in a healthy individual. (B) Same plots seen in a patient with PAH, with increase in the slope of V_E versus VCO₂ and increase in the nadir of V_E/VCO₂ versus time.

I: intercept; RCP: respiratory compensation point; Rec: recovery; S: slope; V_E: minute ventilation; VCO₂: carbon dioxide production; VT: ventilatory threshold; PAH: pulmonary arterial hypertension.

Reprinted with permission of the American Thoracic Society. Copyright © 2019 American Thoracic Society. From: Neder JA, Ramos RP, Ota-Arakaki JS, et al. Exercise intolerance in pulmonary arterial hypertension. The role of cardiopulmonary exercise testing. Ann Am Thorac Soc 2015; 12:604. Annals of the American Thoracic Society is an official journal of the American Thoracic Society.

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Changes in the relationship between VE and VCO2 during exercise in patients with pulmonary vascular disease

Changes in the relationship between V_E and VCO₂ during exercise in patients with pulmonary vascular disease