Sarcomeric gene mutations causing hypertrophic cardiomyopathy

Disease-causing		Prevalence in patients with HCM
Cardiac myosin-binding protein C gene	MYBPC3	Up to 30%
Cardiac beta-myosin heavy chain gene	MYH7	Up to 25%
Cardiac troponin T gene	TNNT2	4 to 15%
Cardiac troponin I gene	TNNI3	2 to 7%
Myosin regulatory light chain gene	MYL2	Rare
Myosin essential light chain gene	MYL3	Rare
Alpha-cardiac actin gene	ACTC1	Rare
Tropomyosin 1 gene	TPM1	Rare
Possibly disease-causing		Prevalence in patients with HCM
Cardiac troponin C gene	TNNC1
Junctophilin 2 gene	JPH2
Cysteine and glycine rich protein 3 gene	CSRP3

Prevalence varies between different populations. Prevalence figures in table are approximations and reflect data from multiple studies.

HCM: hypertrophic cardiomyopathy.

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