Histologic classification of pseudomyxoma peritonei^[1]

Pathologic lesion	Criteria
Acellular mucin	Mucin within the peritoneal cavity without neoplastic epithelial cells
Low-grade mucinous carcinoma peritonei (DPAM)	Epithelial component typically scanty Minimal cytologic atypia Strips, gland-like structures, or small cell clusters
High-grade mucinous carcinoma peritonei (PMCA)	Relatively more cellular Cribriform growth pattern High-grade cytologic atypia Numerous mitoses
High-grade mucinous carcinoma peritonei with signet rings cells (PMCA-S)	Any lesion with a signet ring cell component, that is, round cells with intracytoplasmic mucin pushing the nucleus against the cell membrane

DPAM: disseminated peritoneal adenomucinosis; PMCA: peritoneal mucinous carcinomatosis; PMCA-S: peritoneal mucinous carcinomatosis with signet ring cells.

Reference:

Glasgow SC, Gaertner W, Stewart D, et al. The American Society of Colon and Rectal Surgeons, Clinical Practice Guidelines for the Management of Appendiceal Neoplasms. Dis Colon Rectum 2019; 62:1425.

Modified with permission from: Carr NJ, Bibeau F, Bradley RF, et al. The histopathological classification, diagnosis and differential diagnosis of mucinous appendiceal neoplasms, appendiceal adenocarcinomas and pseudomyxoma peritonei. Histopathology 2017; 71(6):847-858. https://onlinelibrary.wiley.com/doi/abs/10.1111/his.13324. Copyright © 2017 John Wiley & Sons Ltd. Reproduced with permission of John Wiley & Sons Inc. This image has been provided by or is owned by Wiley. Further permission is needed before it can be downloaded to PowerPoint, printed, shared or emailed. Please contact Wiley's permissions department either via email: [email protected] or use the RightsLink service by clicking on the 'Request Permission' link accompanying this article on Wiley Online Library (https://onlinelibrary.wiley.com/).

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Histologic classification of pseudomyxoma peritonei[1]

Histologic classification of pseudomyxoma peritonei^[1]