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تعداد آیتم قابل مشاهده باقیمانده: 4

Mechanisms of action of drugs used for neuropathic pain

Mechanisms of action of drugs used for neuropathic pain
  • Gabapentin/pregabalin: Modulate voltage-gated calcium channels
  • Carbamazepine/oxcarbazepine: Block voltage-dependent sodium channels
  • Tricyclic antidepressants: Inhibit NE>5-HT reuptake, block sodium and calcium channels and NMDA receptors
  • 5-HT/NE reuptake inhibitors: Inhibit 5-HT/NE reuptake
NE: norepinephrine; 5-HT: 5 hydroxytryptamine (serotonin).
Adapted from:
  1. Finnerup NB, Sindrup SH, Jensen TS. Chronic neuropathic pain: mechanisms, drug targets and measurement. Fundam Clin Pharmacol 2007; 21:129.
  2. Tauben D. Nonopioid medications for pain. Phys Med Rehabil Clin N Am 2015; 26:219.
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