Associated diseases with LGL leukemia*

	Frequency (%)
Neoplasms	4 to 10
Autoimmune cytopenia Pure red cell aplasia Autoimmune hemolytic anemia Idiopathic thrombocytopenic purpura Evans syndrome	5
B cell lymphoid neoplasms Low-grade non-Hodgkin lymphoma Diffuse large B cell lymphoma Mantle cell lymphoma Multiple myeloma Chronic lymphocytic leukemia Hairy cell leukemia Waldenström macroglobulinemia Hodgkin lymphoma Lymphomatoid granulomatosis Heavy chain disease	5
Autoimmune diseases/connective tissue disorders	10 to 20
Rheumatoid arthritis Systemic lupus erythematosus Vasculitis Systemic sclerosis Endocrinopathy Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy Multiple endocrine neoplasia type 1 Hashimoto disease Grave disease Chronic inflammatory bowel disease Celiac disease Sjögren's disease Glomerulonephritis Polymyositis Inclusion body myositis Poly/multinevritis Rhizomelic pseudopolyarthritis Inflammatory arthritis (unclassified) Lambert-Eaton myasthenic syndrome Good syndrome Behcet disease Multiple sclerosis Acquired factor VIII inhibitor	10 to 18
Myelodysplastic syndrome	3 to 10
Acute myeloid leukemia	<1
Hemophagocytic syndrome	<1
Pulmonary hypertension	<1
Post-organ or hematopoietic stem cell transplantation	<1
Post viral infection	<1

* Some patients presented with more than one auto-immune-associated disease.

Republished with permission of the American Society of Hematology, from: Lamy T, Moignet A, Loughran TP. LGL leukemia: From pathogenesis to treatment. Blood 2017; 129:1082; permission conveyed through Copyright Clearance Center, Inc. Copyright © 2017.

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Associated diseases with LGL leukemia*