- Cardiovascular dysfunction
- Shock, cardiac arrest (absence of pulse/heart beat and loss of consciousness), use of continuous vasoactive drugs, cardiopulmonary resuscitation, severe hypoperfusion (lactate >5 mmol/L or >45 mg/dL), severe acidosis (pH <7.1)
- Respiratory dysfunction
- Acute cyanosis, gasping, severe tachypnea (respiratory rate >40 breaths per minute), severe bradypnea (respiratory rate <6 breaths per minute), intubation and ventilation not related to anesthesia, severe hypoxemia (O2 saturation <90% for ≥60 minutes or PaO2/FiO2 <200)
- Renal dysfunction
- Oliguria nonresponsive to fluids or diuretics, dialysis for acute renal failure, severe acute azotemia (creatinine ≥300 micromol/mL or ≥3.5 mg/dL)
- Coagulation/hematological dysfunction
- Failure to form clots, massive transfusion of blood or red cells (≥5 units), severe acute thrombocytopenia (<50,000 platelets/mL)
- Hepatic dysfunction
- Jaundice in the presence of preeclampsia, severe acute hyperbilirubinemia (bilirubin >100 micromol/L or >6.0 mg/dL)
- Neurological dysfunction
- Prolonged unconsciousness (lasting ≥12 hours)/coma (including metabolic coma), stroke, uncontrollable fits/status epilepticus, total paralysis
- Uterine dysfunction
- Uterine hemorrhage or infection leading to hysterectomy
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