ﺑﺎﺯﮔﺸﺖ ﺑﻪ ﺻﻔﺤﻪ ﻗﺒﻠﯽ
خرید پکیج
تعداد آیتم قابل مشاهده باقیمانده : 3 مورد
نسخه الکترونیک
medimedia.ir

Local anesthetic dosing for pediatric regional anesthesia*[1,2]

Local anesthetic dosing for pediatric regional anesthesia*[1,2]
Regional anesthetic/usual drugs Maximum recommended doses of LA
Wound infiltration:
  • 0.2% Ropivacaine (2 mg/mL) or
  • 0.25% Bupivacaine (2.5 mg/mL)
  • Use minimal volume required, not to exceed maximum recommended doses
Peripheral nerve blocks:
  • 0.2% Ropivacaine (2 mg/mL) or
  • 0.25% Bupivacaine: (2.5 mg/mL)
  • Upper extremity blocks (eg, brachial plexus), lower extremity blocks (eg, femoral, sciatic, popliteal, or adductor canal block), interfascial plane blocks (TAP, rectus sheath, fascia iliaca ): 0.5 to 1.5 mg/kg
    • Bupivacaine: 0.2 to 0.6 mL/kg
    • Ropivacaine: 0.25 to 0.75 mL/kg
    • With ultrasound guidance, lower volumes may be adequate for nerve blocks. Significant local anesthetic absorption may occur with extended fascial plane blocks
  • Ilioinguinal /Iliohypogastric: 0.25 mg/kg bupivacaine or 0.2 mg/kg ropivacaine (0.1 to 0.2 mL/kg of either drug is usually sufficient for this block)
Caudal block:
  • 0.2% Ropivacaine (2 mg/mL)
  • 0.25% Bupivacaine: (2.5 mg/mL)
  • Modify single-shot volume to achieve appropriate dermatomal level:
    • To a T10 level: 0.5 mL/kg (ie, 1 mg/kg ropivacaine or 1.25 mg/kg bupivacaine)
    • T10 to low-thoracic level: 1 mL/kg (ie, 2 mg/kg ropivacaine or 2.5 mg/kg bupivacaine)
  • Maximum volume for single shot caudal: <20 mL
Lumbar or thoracic epidural
Intraoperative loading dose:
  • 0.2% Ropivacaine (2 mg/mL)
  • 0.25% Bupivacaine: (2.5 mg/mL)
  • Usual initial lumbar loading dose:
    • 0.5 mL/kg (ie, 2 mg/kg ropivacaine or 2.5 mg/kg bupivacaine)
    • Maximum recommended volume <15 mL (fractionated)
  • Usual initial thoracic loading dose:
    • 0.3 mL/kg (ie, 0.6 mg/kg ropivacaine or 0.75 mg/kg bupivacaine), not to exceed 0.68 mL/kg = 1.7 mg/kg
    • Maximum recommended volume <8 mL (fractionated)

Postoperative epidural infusion

Usual drug concentrations:
  • Bupivacaine: 0.0625 to 0.1% (0.625 to 1 mg/mL)
  • Ropivacaine: 0.1% (1 mg/mL)
  • 2-chlorprocaine: 1.5% (15 mg/mL)
Continuous infusion:
  • <3 months of age: Bupivacaine, ropivacaine, or chloroprocaine 0.2 mg/kg/hour
  • 3 months to ≤1 year of age: Bupivacaine, ropivacaine, or chloroprocaine: 0.3 mg/kg/hour
  • >1 year of age: Bupivacaine or ropivacaine: 0.4 mg/kg/hour, chloroprocaine: 0.5 mg/kg/hour
PCEA (for children >30 kg and capable of understanding pump function):
  • Demand dose: 0.5 to 3 mL/dose (if utilized)
  • Lockout interval: 30 to 60 minutes
  • Continuous infusion: Usually ≤15 mL/hour for lumbar epidural, ≤7.5 mL/hour for thoracic epidural, for children >60 kg
  • Maximum hourly dose (ie, continuous infusion dose + PCEA demand doses): ≤0.4 mg/kg/hour
Maximum allowable doses  
Drug: Maximum dose (mg/kg) without/with epinephrine
Lidocaine 4.5/7
Bupivacaine 2.5/3
Ropivacaine 3/3.5
2-Chloroprocaine 11/14
This table shows evidence and consensus based recommendations for safe and effective doses of local anesthetics for regional analgesia in children. Maximum doses represent general guidelines. Local anesthetic systemic toxicity can occur with doses below the recommended range, particularly with intravascular injection. Doses in excess of the recommended maximums have been administered without toxicity. Familiarity with and utilization of ultrasound guidance for peripheral nerve blocks may improve safety and achieve more reliable analgesia with a decreased in drug dose. If an increased volume of local anesthetic is required a lower concentration may be considered.
TAP: transversus abdominus plane.
* Experience in performing central blocks in children is mandatory. All central local anesthetic solutions must be preservative-free and doses administered incrementally with hemodynamic and respiratory monitoring. Ultrasound guidance is recommended for all peripheral nerve blocks.
¶ Single or fractionated single dose only based on lean body weight; not infusion or repetitive dose within 24 hours.
References:
  1. Vittinghoff M, Lönnqvist PA, Mossetti V, et al. Postoperative pain management in children: Guidance from the pain committee of the European Society for Paediatric Anaesthesiology (ESPA Pain Management Ladder Initiative). Paediatr Anaesth 2018; 28:493.
  2. Suresh S, Ecoffey C, Bosenberg A, et al. The European Society of Regional Anaesthesia and Pain Therapy/American Society of Regional Anesthesia and Pain Medicine Recommendations on Local Anesthetics and Adjuvants Dosage in Pediatric Regional Anesthesia. Reg Anesth Pain Med 2018; 43:211.
Graphic 127523 Version 3.0

آیا می خواهید مدیلیب را به صفحه اصلی خود اضافه کنید؟