Evaluations and monitoring | |
Inpatients |
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Outpatients |
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Management | |
Abnormal coagulation studies |
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VTE prophylaxis |
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VTE treatment |
|
Clotting in vascular catheters or extracorporeal circuits* |
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Bleeding |
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aPTT: activated partial thromboplastin time; COVID-19: coronavirus disease 2019; DIC: disseminated intravascular coagulation; DOAC: direct oral anticoagulant; DVT: deep vein thrombosis; ECMO: extracorporeal membrane oxygenation; ICU: intensive care unit; LMW: low molecular weight; MI: myocardial infarction; PE: pulmonary embolism; PERT: pulmonary embolism response team; PT: prothrombin time; tPA: tissue plasminogen activator; VTE: venous thromboembolism.
* Includes continuous renal replacement therapy (hemodialysis), ECMO, or other extracorporeal circuits.
¶ Acute decompensated DIC is associated with clinical bleeding and/or thrombosis and laboratory findings including prolonged PT and aPTT, thrombocytopenia, and hypofibrinogenemia. Antifibrinolytic agents (tranexamic acid and epsilon aminocaproic acid) are avoided because they may tip the balance toward thrombosis. Refer to UpToDate for details.