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تعداد آیتم قابل مشاهده باقیمانده : 3 مورد
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Height outcomes for growth hormone treatment in children with idiopathic short stature (selected studies)

Height outcomes for growth hormone treatment in children with idiopathic short stature (selected studies)
Study Mean height gain Duration of therapy (mean) Adult height reported Comment
Finkelstein 2002[1]
(meta-analysis)		 4 to 6 cm 5.3 years Yes

Short stature defined as stature <10th percentile.

Large number of patients: 1089.
Deodati 2011[2]
(meta-analysis)		 4.7 cm 5.4 years Yes

Small number of patients: 115.

Only randomized trials were included.
Counts 2015[3]
(randomized controlled trial)		 1.3 SDS (approximately 8 cm) 4 years No

Height gain calculated by the height SDS change from baseline to the end of the study (2 to 4 years). Height gain was similar for both treatment groups.

Randomization was to compare 2 different treatment regimens rather than to compare growth hormone with an untreated control group.
Child 2019[4]
(prospective observational study)

8 cm after 4.6 years

10 cm after 6.5 years		 6.5 years Yes

Many patients with delayed bone age were included.

Spontaneous catch-up growth may have contributed to the height gain reported.
In this table, height gain refers to the estimated gain in adult height attributable to growth hormone therapy. Note that these are mean outcomes for the study,and do not capture the wide interindividual variation in response to growth hormone therapy; some patients experience no increase in adult height attributable to growth hormone treatment. In most of these studies, height gain was calculated from the difference between adult height (or near-adult height) at the end of treatment compared with predicted adult height at baseline, irrespective of age. An exception is that, for Counts[3], height gain was calculated by the height SDS change from baseline to the end of the study (2 to 4 years).
SD: standard deviation score.
References:
  1. Finkelstein BS, Imperiale TF, Speroff T, et al. Effect of growth hormone therapy on height in children with idiopathic short stature: a meta-analysis. Arch Pediatr Adolesc Med 2002; 156:230.
  2. Deodati A, Cianfarani S. Impact of growth hormone therapy on adult height of children with idiopathic short stature: systematic review. BMJ 2011; 342:c7157.
  3. Counts DR, Silverman LA, Rajicic N, et al. A 4-Year, Open-Label, Multicenter, Randomized Trial of Genotropin® Growth Hormone in Patients with Idiopathic Short Stature: Analysis of 4-Year Data Comparing Efficacy, Efficiency, and Safety Between an Individualized, Target-Driven Regimen and Standard Dosing. Horm Res Paediatr 2015; 84:79.
  4. Child CJ, Quigley CA, Cutler GB Jr, et al. Height Gain and Safety Outcomes in Growth Hormone-Treated Children with Idiopathic Short Stature: Experience from a Prospective Observational Study. Horm Res Paediatr 2019; 91:241.
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