Overall management approach of resistant hypertension in adults

RAS: renin angiotensin system; CCB: calcium channel blocker; BP: blood pressure; MRA: mineralocorticoid receptor antagonist.
* These diuretics maintain efficacy down to estimated glomerular filtration rates (eGFRs) of 30 mL/min/1.73 m².
¶ Use caution if eGFR is <30 mL/min/1.73 m².
Δ Requires concomitant use of a beta blocker and diuretic.
◊ Requires the concomitant use of a beta blocker and loop diuretic.