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Flortaucipir F-18: Drug information

Flortaucipir F-18: Drug information
(For additional information see "Flortaucipir F-18: Patient drug information")

For abbreviations, symbols, and age group definitions used in Lexicomp (show table)
Brand Names: US
  • Tauvid
Pharmacologic Category
  • Radiopharmaceutical
Dosing: Adult
Radioimaging

Radioimaging: IV: 10 mCi (370 MBq).

Dosing: Kidney Impairment: Adult

There are no dosage adjustments provided in the manufacturer's labeling.

Dosing: Hepatic Impairment: Adult

There are no dosage adjustments provided in the manufacturer's labeling.

Dosing: Older Adult

Refer to adult dosing.

Adverse Reactions

The following adverse drug reactions and incidences are derived from product labeling unless otherwise specified.

1% to 10%:

Local: Pain at injection site (1%)

Nervous system: Headache (1%)

<1%: Cardiovascular: Increased blood pressure

Contraindications

There are no contraindications listed in the manufacturer's labeling.

Warnings/Precautions

Disease-related concerns:

• Malignancy: Patients are exposed to some radiation during treatment; large cumulative amounts of radiation exposure may increase the risk of cancer.

Special handling:

• Radiopharmaceutical: Use appropriate precautions for handling, disposal, and minimizing exposure to patients and health care personnel. Use only under supervision of individuals with experience/training in the handling of radioactive materials approved by the applicable regulatory authority.

Other warnings/precautions:

• Experienced staff: Images should only be interpreted by specially trained personnel.

• Limitations: Only uptake of tracer in neocortex should be used to interpret a positive scan. Small foci of noncontiguous tracer uptake may lead to a false-positive scan. Interpret scans that have isolated or noncontiguous, small foci in any region with caution. In patients with a negative scan, consider additional evaluation; neurofibrillary tangles may still be present at levels that qualify for diagnosis of Alzheimer disease. The ability to detect tau pathology may be lower in patients with earlier stages of disease. Imaging does not target β-amyloid.

Dosage Forms: US

Excipient information presented when available (limited, particularly for generics); consult specific product labeling. [DSC] = Discontinued product

Solution, Intravenous:

Tauvid: 300-1900 MBQ/ML (1 ea [DSC]); 300-3700 MBQ/ML (1 ea) [contains alcohol, usp]

Generic Equivalent Available: US

No

Pricing: US

Solution (Tauvid Intravenous)

300-3700 mbq/ml (per each): $4,200.00

Disclaimer: A representative AWP (Average Wholesale Price) price or price range is provided as reference price only. A range is provided when more than one manufacturer's AWP price is available and uses the low and high price reported by the manufacturers to determine the range. The pricing data should be used for benchmarking purposes only, and as such should not be used alone to set or adjudicate any prices for reimbursement or purchasing functions or considered to be an exact price for a single product and/or manufacturer. Medi-Span expressly disclaims all warranties of any kind or nature, whether express or implied, and assumes no liability with respect to accuracy of price or price range data published in its solutions. In no event shall Medi-Span be liable for special, indirect, incidental, or consequential damages arising from use of price or price range data. Pricing data is updated monthly.

Administration: Adult

IV: Administer as a single IV bolus injection in a total volume of ≤10 mL. Following the injection, flush with NS. Initiate imaging ~80 minutes after injection. Refer to manufacturer's labeling for additional administration information.

Radiopharmaceutical; use appropriate precautions for handling and disposal. Waterproof gloves should be worn and effective shielding should be used during handling and administration.

Use: Labeled Indications

Radioimaging: For use with positron emission tomography (PET) imaging of the brain to estimate the density and distribution of aggregated tau neurofibrillary tangles (NFTs) in adult patients with cognitive impairment who are being evaluated for Alzheimer disease.

Limitations of use: Not indicated for use in the evaluation of patients for chronic traumatic encephalopathy (CTE).

Medication Safety Issues
Sound-alike/look-alike issues:

Flortaucipir F18 may be confused with Florbetaben F18, Florbetapir F18, Fluciclovine F 18, Fludeoxyglucose F 18, Fluoroestradiol F18, and Flutemetamol F18.

Other safety concerns:

Radiopharmaceutical: Use appropriate precaution for handling, disposal, and minimizing exposure to patients and health care personnel. Use under supervision of experienced personnel. Should be stored in original lead container or adequate radiation shield.

Metabolism/Transport Effects

None known.

Drug Interactions

There are no known significant interactions.

Reproductive Considerations

Evaluate pregnancy status prior to use in females of reproductive potential.

Pregnancy Considerations

All radiopharmaceuticals have the potential to cause fetal harm if exposure occurs during pregnancy.

Breastfeeding Considerations

It is not known if flortaucipir F18 is present in breast milk.

Breastfeeding is not recommended by the manufacturer for 4 hours after administration to minimize potential exposure to a breastfed infant.

Monitoring Parameters

Evaluate pregnancy status prior to use in females of reproductive potential.

Mechanism of Action

Flortaucipir F18 binds to aggregated tau protein; the F18 isotope produces a positron signal that is detected by a positron emission tomography scanner.

Pharmacokinetics (Adult Data Unless Noted)

Distribution: <10% of F18 radioactivity present in blood 5 minutes post administration; <5% of F18 radioactivity present in blood 10 minutes post administration.

Excretion: Hepatobiliary and renal.

  1. Tauvid (flortaucipir F18) [prescribing information]. Philadelphia, PA: Eli Lilly and Company; July 2022.
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