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ISSVD and LAST terminology[1-4]

ISSVD and LAST terminology[1-4]
Year of publication and expert group 1986 ISSVD 2004 ISSVD 2012 LAST 2015 ISSVD
Terminology VIN 1 (mild dysplasia)* Condyloma (HPV effect)* LSIL* LSIL of the vulva (vulvar LSIL, flat condyloma, or HPV effect)*

VIN 2 (moderate dysplasia)*

VIN 3 (severe dysplasia)*

VIN 3 (carcinoma in situ)*		 VIN, usual type:*
  • VIN, warty type
  • VIN, basaloid type
  • VIN, mixed (warty or basaloid type)
 HSIL* HSIL (vulvar HSIL, VIN usual type)*
Differentiated VIN VIN differentiated N/A (no alternative terminology for dVIN) Differentiated VIN
ISSVD: International Society for the Study of Vulvovaginal Disease; LAST: Lower Anogenital Squamous Terminology; VIN: vaginal intraepithelial neoplasia; HPV: human papillomavirus; LSIL: low-grade squamous intraepithelial lesion; HSIL: high-grade squamous intraepithelial lesion; N/A: not applicable; dVIN: differentiated vaginal intraepithelial neoplasia.
* Generally HPV related.
¶ Generally not HPV related.
References:
  1. Wilkinson EJ, Kneal B, Lynch PJ. Report of the ISSVD Terminology Committee. J Reprod Med 1986; 31:973.
  2. Sideri MG, Jones RW, Wilkins EJ, et al. Squamous Vulvar Intraepithelial Neoplasia: 2004 Modified Terminology, ISSVD Vulvar Oncology Subcommittee. J Reprod Med 2005; 50:807.
  3. Bornstein J, Bogliatto F, Haefner HK, et al. The 2015 International Society for the Study of Vulvovaginal Disease (ISSVD) Terminology of Vulvar Squamous Intraepithelial Lesions. J Low Genit Tract Dis 2016; 20:11.
  4. Darragh TM, Colgan TJ, Cox JT, et al. The Lower Anogenital Squamous Terminology Standardization Project for HPV-Associated Lesions: background and consensus recommendations from the College of American Pathologists and the American Society for Colposcopy and Cervical Pathology. J Low Genit Tract Dis 2012; 16:205.
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