Overview of the treatment of medulloblastoma in children

MRI: magnetic resonance imaging; CSF: cerebrospinal fluid; SHH: sonic hedgehog; RT: radiation therapy; CSI: craniospinal irradiation; PS: primary site; HCT: hematopoietic cell transplantation.

* Obtain preoperatively or 2 to 3 weeks postoperatively for optimal specificity.

¶ Molecular subgrouping should be performed on tumor tissue if available; results have prognostic significance and may be used to stratify treatment intensity in clinical trials.