Chemotherapy agents commonly used for heated intraperitoneal chemotherapy^[1,2]

Class	Chemotherapy	Carrier solution	Area under curve (AUC) ratio*	Tissue penetration (mm)	Adverse effects
Platinum-based chemotherapy	Cisplatin	0.9% sodium chloride	7.8	1 to 3	Nephrotoxicity Peripheral neuropathy Myelotoxicity
	Oxaliplatin	5% dextrose	16	1 to 2	Thrombocytopenia Intraperitoneal hemorrhage Electrolyte disturbances (hyponatremia, hyperglycemia)
	Carboplatin	0.9% sodium chloride	18	1	Postoperative nausea Thrombocytopenia
Non-platinum-based chemotherapy	Mitomycin (alkylating tumor antibiotic)	1.5% dextrose dialysis solution	23.5	2	Neutropenia Nephrotoxicity Interstitial lung disease (dose-dependent)
	Doxorubicin (anthracycline antibiotic)	1.5% dextrose dialysis solution	230	4 to 6	Cardiotoxicity (arrhythmias) Myelotoxicity
	Paclitaxel	1.5% dextrose dialysis; 6% hetastarch	1000	N/A	Polyneuropathy
	Flurorouracil	0.9% sodium chloride	280	0.2	Polyneuropathy, cardiotoxicity

N/A: not applicable.
* Concentrations of chemotherapy agents in the peritoneal cavity and the plasma are typically described by the AUC created by plotting the drug concentration over time. The ratio of the peritoneal to plasma AUC is a measure of the degree to which a drug is absorbed. A high AUC ratio is desirable in order to maximize cytotoxicity, while minimizing systemic toxicity. However, a high AUC ratio is only one factor that enters into the choice of intraperitoneal chemotherapy agent, along with efficacy of the drug for the tumor type.

References:

Goodman MD, McPartland S, Detelich D, Said MW. Chemotherapy for intraperitoneal use: a review of hyperthermic intraperitoneal chemotherapy and early post-operative intraperitoneal chemotherapy. J Gastrointest Oncol 2016; 7:45.
de Bree E, Michelakis D, Stamatiou D, et al. Pharmacological principles of intraperitoneal and bidirectional chemotherapy. Pleura Peritoneum 2017; 2:47.

Graphic 129409 Version 3.0

خرید پکیج

Chemotherapy agents commonly used for heated intraperitoneal chemotherapy[1,2]

Chemotherapy agents commonly used for heated intraperitoneal chemotherapy^[1,2]