Criteria for placement on a waitlist for intestinal transplantation*

Evidence of advanced or progressive intestinal failure-associated liver disease:

Hyperbilirubinemia >75 micromol/L^¶ (4.5 mg/dL) despite intravenous lipid modification strategies that persists for >2 months
Any combination of elevated serum bilirubin, reduced synthetic function (subnormal albumin or elevated international normalized ratio), and laboratory indications of portal hypertension and hypersplenism, especially low platelet count, persisting for >1 month in the absence of a confounding infectious event(s)

Thrombosis of 3 out of 4 discrete upper body central veins (left subclavian and internal jugular, right subclavian and internal jugular) or occlusion of a brachiocephalic vein in children (in adults, this criterion should be evaluated in a case-by-case basis)

Life-threatening morbidity in the setting of indefinite parenteral nutrition dependence of either anatomical or functional cause, as suggested by:

In children, 2 admissions to an intensive care unit (after initial recovery from the event resulting in intestinal failure) because of cardiorespiratory failure (mechanical ventilation or inotrope infusion) due to sepsis or other complications of intestinal failure
In adults, on a case-by-case basis

Invasive intra-abdominal desmoids in adolescents and adults

Acute diffuse intestinal infarction with hepatic failure

Failure of first intestinal transplant

* Presuming that patients will have been assessed by a multidisciplinary team, rehabilitation options have been explored, and a state of permanent or life-limiting intestinal failure exists.
¶ A total serum bilirubin of 62 or 70 mmol/L is also associated with increased mortality. A bilirubin level of 75 micromol/L is simply a useful, consensus marker of progressive liver disease to be taken in context with other parameters.

From: Kaufman S, Avitzur Y, Beath S, et al. New insights into the indications for intestinal transplantation: Consensus in the year 2019. Transplantation 2020; 104:937. DOI: 10.1097/TP.0000000000003065. Copyright © 2020. Reproduced with permission from Wolters Kluwer Health. Unauthorized reproduction of this material is prohibited.

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Criteria for placement on a waitlist for intestinal transplantation*