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Dimethicone (dimeticone) (topical): Drug information

Dimethicone (dimeticone) (topical): Drug information
(For additional information see "Dimethicone (dimeticone) (topical): Pediatric drug information" and see "Dimethicone (dimeticone) (topical): Patient drug information")

For abbreviations, symbols, and age group definitions used in Lexicomp (show table)
Brand Names: US
  • Cavilon Durable Barrier [OTC] [DSC];
  • CeraVe Baby [OTC] [DSC];
  • DermacinRx Skin Repair [OTC];
  • Dimopair [OTC];
  • Moisture Guard [OTC] [DSC];
  • Moisturizing Skin Protectant [OTC];
  • Remedy Moisture Barrier [OTC] [DSC];
  • Remedy Skin Repair [OTC] [DSC];
  • Restore Cleanser & Moisturizer [OTC];
  • Secura Dimethicone Protectant [OTC];
  • Sween 24 Once a Day [OTC];
  • TheraSeal Hand Protection [OTC]
Pharmacologic Category
  • Protectant, Topical;
  • Topical Skin Product
Dosing: Adult
Skin protectant

Skin protectant: Topical: Apply to affected area as needed.

Dosing: Kidney Impairment: Adult

There are no dosage adjustments provided in the manufacturer's labeling.

Dosing: Hepatic Impairment: Adult

There are no dosage adjustments provided in the manufacturer's labeling.

Dosing: Older Adult

Refer to adult dosing.

Dosing: Pediatric

(For additional information see "Dimethicone (dimeticone) (topical): Pediatric drug information")

Skin protectant

Skin protectant: Infants, Children, and Adolescents: Topical: Apply to affected area(s) as needed.

Dosing: Kidney Impairment: Pediatric

There are no dosage adjustments provided in the manufacturer's labeling.

Dosing: Hepatic Impairment: Pediatric

There are no dosage adjustments provided in the manufacturer's labeling.

Adverse Reactions

No ADRs in manufacturer's labeling.

Contraindications

There are no contraindications listed in the manufacturer's labeling.

Warnings/Precautions

Other warnings/precautions:

• Self-medication (OTC use): For external use only. Avoid contact with eyes; flush with water with accidental contact. Do not apply to animal bites, deep puncture wounds, infected skin, or serious burns. Notify health care provider if symptoms worsen, do not improve within 7 days, or clear up and reoccur within a few days.

Dosage Forms: US

Excipient information presented when available (limited, particularly for generics); consult specific product labeling. [DSC] = Discontinued product

Cream, External:

Cavilon Durable Barrier: 1.3% (92 g [DSC]) [fragrance free, latex free; contains benzoic acid]

DermacinRx Skin Repair: 5% (118 mL) [contains cetyl alcohol, disodium edta, trolamine (triethanolamine)]

Dimopair: 5% (118 mL) [contains cetyl alcohol, edetate (edta) disodium]

Moisture Guard: 5% (85 g [DSC]) [contains methylparaben, propylparaben]

Moisturizing Skin Protectant: 8% (113 g, 198 g, 255 g) [contains cetyl alcohol, methylparaben, propylene glycol, propylparaben]

Remedy Moisture Barrier: 5% (118 mL [DSC]) [contains cetyl alcohol, edetate (edta) sodium (tetrasodium), methylparaben, propylparaben, trolamine (triethanolamine)]

Remedy Skin Repair: 1.5% (4 mL [DSC], 59 mL [DSC], 118 mL [DSC], 946 mL [DSC]) [contains cetyl alcohol, edetate (edta) sodium (tetrasodium), methylparaben, propylparaben, trolamine (triethanolamine)]

Secura Dimethicone Protectant: 5% (114 g) [fragrance free; contains disodium edta, methylparaben, propylene glycol, propylparaben]

Sween 24 Once a Day: 6% (57 g) [contains cetyl alcohol]

Liquid, External:

Restore Cleanser & Moisturizer: 2% (222 mL, 340 mL) [contains butylparaben, cetearyl alcohol, ethylparaben, isobutylparaben, methylparaben, propylparaben, trolamine (triethanolamine)]

Lotion, External:

CeraVe Baby: 1% (237 mL [DSC]) [fragrance free, paraben free, sulfate free; contains cetostearyl alcohol, cetyl alcohol, disodium edta]

TheraSeal Hand Protection: 1% (180 g)

Generic Equivalent Available: US

May be product dependent

Pricing: US

Cream (DermacinRx Skin Repair External)

5% (per mL): $15.55

Cream (Dimopair External)

5% (per mL): $13.05

Cream (Secura Dimethicone Protectant External)

5% (per gram): $0.09

Cream (Sween 24 Once a Day External)

6% (per gram): $0.08

Liquid (Restore Cleanser & Moisturizer External)

2% (per mL): $0.04

Lotion (TheraSeal Hand Protection External)

1% (per gram): $0.12

Disclaimer: A representative AWP (Average Wholesale Price) price or price range is provided as reference price only. A range is provided when more than one manufacturer's AWP price is available and uses the low and high price reported by the manufacturers to determine the range. The pricing data should be used for benchmarking purposes only, and as such should not be used alone to set or adjudicate any prices for reimbursement or purchasing functions or considered to be an exact price for a single product and/or manufacturer. Medi-Span expressly disclaims all warranties of any kind or nature, whether express or implied, and assumes no liability with respect to accuracy of price or price range data published in its solutions. In no event shall Medi-Span be liable for special, indirect, incidental, or consequential damages arising from use of price or price range data. Pricing data is updated monthly.

Administration: Adult

Topical: For external use only; avoid contact with eyes. Formulation-specific application instructions may vary; also refer to manufacturer's labeling.

Administration: Pediatric

Topical: For external use only; avoid contact with eyes. Do not use on deep or puncture wounds, animal bites, or serious burns. Formulation-specific application instructions may vary; refer to manufacturer's labeling.

Use: Labeled Indications

Skin protectant: To protect and prevent chafed, chapped, cracked, or windburned skin or lips or other minor skin irritations (eg, diaper rash, perineal dermatitis). Product-specific indications may vary; also refer to manufacturer's labeling.

Medication Safety Issues
Look alike/sound alike issues:

Dimethicone may be confused with simethicone.

International issues:

Hedrin brand name for dimethicone (topical) [United Kingdom] may be confused with Hedrin brand name for simethicone [Israel].

Baritex brand name for dimethicone (topical) [Singapore] may be confused with Barex brand name for polyethylene glycol-electrolyte solution [Argentina].

Metabolism/Transport Effects

None known.

Drug Interactions

There are no known significant interactions.

Pregnancy Considerations

Dimethicone is not absorbed systemically following topical administration (Nair 2003). Use during pregnancy would not be expected to result in significant exposure to the fetus.

Breastfeeding Considerations

Dimethicone is not absorbed systemically following topical administration (Nair 2003). Exposure via breast milk would not be expected.

Mechanism of Action

Forms a protective layer on the skin that acts as a barrier to moisture loss and a protector against repeated hydration and chemical irritants.

Pharmacokinetics (Adult Data Unless Noted)

Absorption: Little to no absorption.

Brand Names: International
International Brand Names by Country
For country code abbreviations (show table)

  • (AR) Argentina: Kinderval total | Skinderm SIL;
  • (AU) Australia: Cavilon | Dermofilm | Dimethicone | Egozite baby | Linicin | Rosken skin repair | Silcon | Silicare;
  • (CL) Chile: Nopiox | Para | Refellin | Sensei;
  • (DE) Germany: EtoPril | Linicin | Silgel | Unguentum Dimeticoni SR;
  • (EG) Egypt: Barrisilic;
  • (GB) United Kingdom: Hedrin | Hedrin stubborn egg loosening | Hedrin Treat & Go;
  • (HK) Hong Kong: Silic | Skin Repair;
  • (IE) Ireland: Linicin;
  • (IL) Israel: Hedrin | Silicone;
  • (JO) Jordan: Cavilon;
  • (MY) Malaysia: Aloe vesta skin conditioner | Silic | Skin Repair Dry Skin;
  • (NL) Netherlands: XTLuis;
  • (NZ) New Zealand: Dimethicone | Dp Barrier | Healthe dimethicone | Silic | Silicare;
  • (PR) Puerto Rico: Ceramax | Mederma pm | One Step Perineal | Proshield plus | Remedy 4-In-1 Cleansing | Remedy Dimethicone | Remedy Nutrashield | Remedy Skin Repair | Soothe & cool inzo barrier | Vaniply;
  • (SA) Saudi Arabia: Fixoderm;
  • (SG) Singapore: Baritex | Rosken skin repair | Silic | Silicone | Skin Repair;
  • (UA) Ukraine: Headring | Hedrin;
  • (UY) Uruguay: Cavilon;
  • (VE) Venezuela, Bolivarian Republic of: Piokilin;
  • (ZA) South Africa: Controlice head rinse | Proglyde
  1. 4-N-1 (dimethicone) cream [prescribing information]. North Bergen, NJ: DermaRite Industries LLC; received September 2020.
  2. AloeVesta (dimethicone) lotion [prescribing information]. Greensboro, NC: ConvaTec Inc; November 2019.
  3. Aveeno (dimethicone) lotion [prescribing information]. Skillman, NJ: Johnson and Johnson Consumer Companies; December 2019.
  4. Aveeno Baby (dimethicone) lotion [prescribing information]. Skillman, NJ: Johnson and Johnson Consumer Companies; received September 2020.
  5. Cavilo Durable Barrier (dimethicone) cream [prescribing information]. St. Paul, MN: 3M Health Care; June 2020.
  6. Comfort Shield Barrier (dimethicone) cream cloths [prescribing information]. Cary, IL: Sage Products LLC; January 2019.
  7. Moisturel (dimethicone) lotion [prescribing information]. Rockaway, NJ: Warner Chilcott (US) LLC; May 2019.
  8. Monistat Care Chafing Relief (dimethicone) powder gel [prescribing information]. Langhorne, PA: Insight Pharmaceuticals LLC; February 2019.
  9. Nair B; Cosmetic Ingredients Review Expert Panel. Final report on the safety assessment of stearoxy dimethicone, dimethicone, methicone, amino bispropyl dimethicone, aminopropyl dimethicone, amodimethicone, amodimethicone hydroxystearate, behenoxy dimethicone, C24-28 alkyl methicone, C30-45 alkyl methicone, C30-45 alkyl dimethicone, cetearyl methicone, cetyl dimethicone, dimethoxysilyl ethylenediaminopropyl dimethicone, hexyl methicone, hydroxypropyldimethicone, stearamidopropyl dimethicone, stearyl dimethicone, stearyl methicone, and vinyldimethicone. Int J Toxicol. 2003;22(suppl 2):S11-S35. [PubMed 14555417]
  10. Proshield Plus (dimethicone) ointment [prescribing information]. Fort Worth, TX: Smith & Nephew Inc; received June 2015.
  11. Remedy Cleansing Body (dimethicone) lotion [prescribing information]. Northfield, IL: Medline Industries Inc; received September 2020.
  12. Vaniply (dimethicone) ointment [prescribing information]. Rochester, MN: Pharmaceutical Specialties Inc; received March 2018.
Topic 129549 Version 170.0

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