Designation* | Parent protein | Systemic and/or localized | Acquired or hereditary | Organs involved |
AL | Immunoglobulin light chain¶ | Systemic or localized | Acquired (hereditaryΔ) | Heart, kidney, liver, soft tissues, peripheral nervous system (including the autonomic nervous system), and gastrointestinal tract |
ATTR | Transthyretin | Systemic | Hereditary | Peripheral nervous system (including the autonomic nervous system), heart, eye, kidney, and leptomeninges |
Systemic | Acquired | Heart and ligaments | ||
AA | Serum amyloid A protein | Systemic | Acquired | Predominantly kidney, but may involve liver, gastrointestinal tract and occasionally heart, thyroid, and autonomic nervous system |
ALECT2 | Leukocyte chemotactic factor 2 | Systemic | Acquired | Kidney, liver, spleen, adrenals, and lungs |
AApoAI | Apolipoprotein AI | Systemic | Hereditary | Heart, liver, kidney, peripheral nervous system, testis, larynx, and skin |
AFib | Fibrinogen alpha chain | Systemic | Hereditary | Kidney, primarily, with obliterative glomerular involvement |
ABeta-2-microglobulin-related amyloidosis | Beta-2-microglobulin, wild type | Systemic | Acquired (hemodialysis related) | Musculoskeletal system |
Beta-2-microglobulin | Systemic | Hereditary | Autonomic nervous system |
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