International Pediatric Liver Tumors Consensus Classification of Hepatoblastoma

Epithelial

Fetal

Fetal with low mitotic activity (well differentiated)

Fetal, mitotically active (crowded fetal)

Pleomorphic

Embryonal

Small cell undifferentiated

SMARCB1 (INI1)-negative

SMARCB1 (INI1)-positive

Cholangioblastic

Macrotrabecular

Mixed epithelial (any/all above)

Mixed epithelial and mesenchymal

Without teratoid features

With teratoid features

SMARCB1: SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin, subfamily B, member 1; INI1: integrase interactor-1.

Adapted by permission from Macmillan Publishers Ltd: Modern Pathology. López-Terrada D, Alaggio R, de Dávila MT, et al. Towards an international pediatric liver tumor consensus classification: proceedings of the Los Angeles COG liver tumors symposium. Mod Pathol 2014; 27:472. https://www.nature.com/modpathol/.

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International Pediatric Liver Tumors Consensus Classification of Hepatoblastoma